肝移植術圍手術期脾亢的處理

作者：蔣安，呂毅，劉昌，李宗芳，李泉源，史源，馬鋒

【關鍵詞】 肝移植；脾功能亢進；移植物排斥；血小板；肺部感染
　　Treatment of hypersplenism in perioperation of liver transplantation
　　【Abstract】AIM: To observe the changes in hypersplenism after orthotopic liver transplantation(OLT)and to investigate the influence of splenectomy or splenic artery ligation before or during liver transplantation on the therapeutic outcome. METHODS: Splenectomy or splenic artery ligation was performed on 15(group A) of the consecutive 115 patients undergoing OLT in 5 years, before OTC in 11 of them and during OTC in 4 of them. Sixtyeight randomly selected agematched patients undergoing OTC within the same period but without splenectomy or splenic artery ligation were used as controls (group B). Acute rejection rate , blood PLT count, incidence of lung infection and PVF/HAF（portal venous flow/ hepatic arterial flow） were calculated and analyzed. RESULTS: Lung infaction rate of group A was 85%, significantly higher than that of group B (54%, P

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